This product is supplied exclusively for in-vitro laboratory research use. It is not intended for human or animal use, including diagnosis, treatment, mitigation, or prevention of disease.
MOTS-c 10mg
$85Purity: 99.862%
Independently Tested
Freedom Diagnostics — USA Lab
Product ID
MOTS-C
Purity
99.862%
Dosage
10mg
Category
Recovery
| Molecular Formula | C₁₀₁H₁₅₂N₂₈O₂₂S₂ |
| Molecular Weight | 2,174.6 Da |
| Sequence | Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg |
| CAS Number | 1627580-64-6 ↗ |
| Purity | 99.862% HPLC |
| Form | Lyophilized Powder |
| Storage | -20°C / -4°F |
Tested by Freedom Diagnostics
HPLC + Mass Spectrometry · USA Lab
About MOTS-c
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino acid peptide (Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg) encoded by the mitochondrial genome — making it one of the few peptides of mitochondrial origin. This unique origin makes MOTS-c a retrograde signaling molecule that communicates mitochondrial metabolic status to the nucleus, representing a novel class of mitochondria-derived peptides (MDPs).
Research indicates MOTS-c regulates metabolic homeostasis through AMPK activation and influences glucose metabolism, insulin sensitivity, and lipid oxidation in skeletal muscle. Studies have demonstrated that MOTS-c enhances glucose uptake and fatty acid beta-oxidation in muscle cells, improving metabolic efficiency. The peptide shows stress-responsive expression patterns — its levels increase during exercise and caloric restriction — suggesting it plays a role in adaptive metabolic responses.
MOTS-c has been investigated in contexts of metabolic syndrome, aging, and exercise adaptation, making it a frontier research target for longevity and metabolic biology.
Research Applications:
- Mitochondria-to-nucleus retrograde signaling studies
- AMPK pathway activation and metabolic regulation research
- Skeletal muscle glucose metabolism and insulin sensitivity studies
- Exercise adaptation and metabolic flexibility research
- Aging and longevity biology investigations
- Mitochondria-derived peptide (MDP) biology research
Key Specifications:
- Purity: 99.862% verified by Freedom Diagnostics testing
- Dosage: 10mg per vial
- Category: Recovery
- Storage: -20°C or colder (lyophilized)
- Stability: Up to 2 years when stored properly
Research Highlights:
- Unique mitochondria-encoded peptide — retrograde nuclear signaling
- AMPK activation promotes glucose uptake and fatty acid oxidation
- Exercise-responsive expression — increases with physical activity
- Age-related decline makes it a longevity research target
- Molecular weight: 2,174.6 Da | CAS: 1627580-64-6 | PubChem CID: 146675088
MOTS-c 10mg
MOTS-c is a mitochondrial-derived peptide that regulates metabolic function and cellular energy. Research suggests it may improve insulin sensitivity, enhance exercise capacity, and support metabolic health—particularly interesting for studies on aging, metabolism, and physical performance.
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MOTS-c
$85